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-Structure paper
Title | Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. |
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Journal, issue, pages | J. Mol. Biol., Vol. 387, Page 219-232, Year 2009 |
Publish date | Oct 20, 2008 (structure data deposition date) |
Authors | Williams, N.K. / Bamert, R.S. / Patel, O. / Wang, C. / Walden, P.M. / Wilks, A.F. / Fantino, E. / Rossjohn, J. / Lucet, I.S. |
External links | J. Mol. Biol. / PubMed:19361440 |
Methods | X-ray diffraction |
Resolution | 1.9 - 2.4 Å |
Structure data | PDB-3eyg: PDB-3eyh: PDB-3fup: |
Chemicals | ChemComp-MI1: ChemComp-HOH: ChemComp-IZA: |
Source |
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Keywords | TRANSFERASE / JAK kinase / ATP-binding / Kinase / Nucleotide-binding / Phosphoprotein / SH2 domain / Tyrosine-protein kinase / PTK domain / Protein-inhibitor complex / Chromosomal rearrangement / Disease mutation / Membrane / Polymorphism / Proto-oncogene |