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Structure paper

TitleCrystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin.
Journal, issue, pagesBiochemistry, Vol. 48, Page 3425-3435, Year 2009
Publish dateJul 14, 2008 (structure data deposition date)
AuthorsEpstein, T.M. / Samanta, U. / Kirby, S.D. / Cerasoli, D.M. / Bahnson, B.J.
External linksBiochemistry / PubMed:19271773
MethodsX-ray diffraction
Resolution1.85 - 2.1 Å
Structure data

PDB-3dt6:
Crystal Structure of Bovin Brain Platelet Activating Factor Acetylhydrolase Covalently Inhibited by Paraoxon
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3dt8:
Crystal Structure of Bovin Brain Platelet Activating Factor Acetylhydrolase Covalently Inhibited by Sarin
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-3dt9:
Crystal Structure of Bovin Brain Platelet Activating Factor Acetylhydrolase Covalently Inhibited by Soman
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-DEP:
DIETHYL PHOSPHONATE

ChemComp-HOH:
WATER

ChemComp-GD7:
(1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE

Source
  • bos taurus (domestic cattle)
KeywordsHYDROLASE / PLATELET ACTIVATING FACTOR ACETYLHYDROLASE / PAF-AH IB / ALPHA-1 SUBUNIT / LIS1 / GROUP VIII PHOSPHOLIPASE A2 / 26 kDa / PARAOXON / Cytoplasm / Lipid degradation / PLATELET FACTOR / SARIN / SOMAN

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