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TitleCombined X-ray and NMR analysis of the stability of the cyclotide cystine knot fold that underpins its insecticidal activity and potential use as a drug scaffold
Journal, issue, pagesJ. Biol. Chem., Vol. 284, Page 10672-10683, Year 2009
Publish dateAug 10, 2008 (structure data deposition date)
AuthorsWang, C.K. / Hu, S.-H. / Martin, J.L. / Sjogren, T. / Hajdu, J. / Bohlin, L. / Claeson, P. / Goransson, U. / Rosengren, K.J. / Tang, J. ...Wang, C.K. / Hu, S.-H. / Martin, J.L. / Sjogren, T. / Hajdu, J. / Bohlin, L. / Claeson, P. / Goransson, U. / Rosengren, K.J. / Tang, J. / Tan, N.-H. / Craik, D.J.
External linksJ. Biol. Chem. / PubMed:19211551
MethodsNMR (solution) / X-ray diffraction
Resolution1.8 Å
Structure data

PDB-2k7g:
Solution Structure of varv F
Method: SOLUTION NMR

PDB-3e4h:
Crystal structure of the cyclotide varv F
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • viola arvensis (European field pansy)
KeywordsPLANT PROTEIN / cyclotide / cystine knot / Knottin / Plant defense / circular proteins / cyclization

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