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Structure paper

TitleSynthesis and SAR of potent LXR agonists containing an indole pharmacophore.
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 19, Page 1097-1100, Year 2009
Publish dateNov 21, 2008 (structure data deposition date)
AuthorsWashburn, D.G. / Hoang, T.H. / Campobasso, N. / Smallwood, A. / Parks, D.J. / Webb, C.L. / Frank, K.A. / Nord, M. / Duraiswami, C. / Evans, C. ...Washburn, D.G. / Hoang, T.H. / Campobasso, N. / Smallwood, A. / Parks, D.J. / Webb, C.L. / Frank, K.A. / Nord, M. / Duraiswami, C. / Evans, C. / Jaye, M. / Thompson, S.K.
External linksBioorg. Med. Chem. Lett. / PubMed:19167885
MethodsX-ray diffraction
Resolution2.063 Å
Structure data

PDB-3fc6:
hRXRalpha & mLXRalpha with an indole Pharmacophore, SB786875
Method: X-RAY DIFFRACTION / Resolution: 2.063 Å

Chemicals

ChemComp-REA:
RETINOIC ACID

ChemComp-LX2:
[4-(3-{[2-chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino}propoxy)-1H-indol-1-yl]acetic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsTRANSCRIPTION / Liver X receptor / nuclear hormone receptors / agonists / epoxycholesterol / DNA-binding / Host-virus interaction / Metal-binding / Nucleus / Polymorphism / Receptor / Transcription regulation / Ubl conjugation / Zinc / Zinc-finger

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