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-Structure paper
Title | Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 1050-1062, Year 2009 |
Publish date | Nov 26, 2008 (structure data deposition date) |
Authors | Coumar, M.S. / Leou, J.S. / Shukla, P. / Wu, J.S. / Dixit, A.K. / Lin, W.H. / Chang, C.Y. / Lien, T.W. / Tan, U.K. / Chen, C.H. ...Coumar, M.S. / Leou, J.S. / Shukla, P. / Wu, J.S. / Dixit, A.K. / Lin, W.H. / Chang, C.Y. / Lien, T.W. / Tan, U.K. / Chen, C.H. / Hsu, J.T.A. / Chao, Y.S. / Wu, S.Y. / Hsieh, H.P. |
External links | J. Med. Chem. / PubMed:19140666 |
Methods | X-ray diffraction |
Resolution | 1.9 Å |
Structure data | PDB-3fdn: |
Chemicals | ChemComp-MMH: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / Aurora kinase inhibitors / Virtual screening / X-ray co-crystal analysis / Structure-based drug design (SBDD) / H-bonding. / ATP-binding / Cell cycle / Kinase / Nucleotide-binding / Phosphoprotein / Polymorphism / Serine/threonine-protein kinase |