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-Structure paper
Title | Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 18, Page 6352-6356, Year 2008 |
Publish date | Oct 1, 2008 (structure data deposition date) |
Authors | Kopecky, D.J. / Hao, X. / Chen, Y. / Fu, J. / Jiao, X. / Jaen, J.C. / Cardozo, M.G. / Liu, J. / Wang, Z. / Walker, N.P. ...Kopecky, D.J. / Hao, X. / Chen, Y. / Fu, J. / Jiao, X. / Jaen, J.C. / Cardozo, M.G. / Liu, J. / Wang, Z. / Walker, N.P. / Wesche, H. / Li, S. / Farrelly, E. / Xiao, S.H. / Kayser, F. |
External links | Bioorg. Med. Chem. Lett. / PubMed:18993068 |
Methods | X-ray diffraction |
Resolution | 2 - 2.3 Å |
Structure data | PDB-3eqp: PDB-3eqr: |
Chemicals | ChemComp-T95: ChemComp-CL: ChemComp-HOH: ChemComp-T74: |
Source |
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Keywords | TRANSFERASE / ack1 / Alternative splicing / ATP-binding / Cell membrane / Kinase / Magnesium / Membrane / Metal-binding / Nucleotide-binding / Phosphoprotein / Polymorphism / SH3 domain / Tyrosine-protein kinase |