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Structure paper

TitleStructure of the intracellular domain of the amyloid precursor protein in complex with Fe65-PTB2.
Journal, issue, pagesEmbo Rep., Vol. 9, Page 1134-1140, Year 2008
Publish dateJul 24, 2008 (structure data deposition date)
AuthorsRadzimanowski, J. / Simon, B. / Sattler, M. / Beyreuther, K. / Sinning, I. / Wild, K.
External linksEmbo Rep. / PubMed:18833287
MethodsX-ray diffraction
Resolution2 - 2.2 Å
Structure data

PDB-3dxc:
Crystal structure of the intracellular domain of human APP in complex with Fe65-PTB2
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-3dxd:
Crystal structure of the intracellular domain of human APP (T668E mutant) in complex with Fe65-PTB2
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-3dxe:
Crystal structure of the intracellular domain of human APP (T668A mutant) in complex with Fe65-PTB2
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Alzheimer's disease / APP / AICD / Fe65 / PTB domain / Alzheimer disease / Amyloid / Apoptosis / Cell adhesion / Coated pit / Disease mutation / Endocytosis / Glycoprotein / Heparin-binding / Iron / Membrane / Metal-binding / Notch signaling pathway / Phosphoprotein / Protease inhibitor / Proteoglycan / Serine protease inhibitor / Transmembrane

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