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Structure paper

TitleCrystal structures of the pro-inflammatory cytokine interleukin-23 and its complex with a high-affinity neutralizing antibody
Journal, issue, pagesJ. Mol. Biol., Vol. 382, Page 942-955, Year 2008
Publish dateMay 22, 2008 (structure data deposition date)
AuthorsBeyer, B.M. / Ingram, R. / Ramanathan, L. / Reichert, P. / Le, H.V. / Madison, V. / Orth, P.
External linksJ. Mol. Biol. / PubMed:18708069
MethodsX-ray diffraction
Resolution1.9 - 2.9 Å
Structure data

PDB-3d85:
Crystal structure of IL-23 in complex with neutralizing FAB
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-3d87:
Crystal structure of Interleukin-23
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-IMD:
IMIDAZOLE

ChemComp-MPD:
(4S)-2-METHYL-2,4-PENTANEDIOL / precipitant*YM

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-K:
Unknown entry

ChemComp-MAN:
alpha-D-mannopyranose

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM/CYTOKINE / Interleukin-23 / FAB / IMMUNE SYSTEM-CYTOKINE COMPLEX / CYTOKINE

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