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-Structure paper
Title | Targeted Rescue of a Destabilized Mutant of P53 by an in Silico Screened Drug. |
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Journal, issue, pages | Proc. Natl. Acad. Sci. USA, Vol. 105, Page 10360-, Year 2008 |
Publish date | May 26, 2008 (structure data deposition date) |
![]() | Boeckler, F.M. / Joerger, A.C. / Jaggi, G. / Rutherford, T.J. / Veprintsev, D.B. / Fersht, A.R. |
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Methods | X-ray diffraction |
Resolution | 1.5 Å |
Structure data | ![]() PDB-2vuk: |
Chemicals | ![]() ChemComp-ZN: ![]() ChemComp-P83: ![]() ChemComp-HOH: |
Source |
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![]() | TRANSCRIPTION / METAL BINDING / PHOSPHOPROTEIN / UBL CONJUGATION / ACTIVATOR / CELL CYCLE / ACETYLATION / METHYLATION / ZINC / CANCER / NUCLEUS / APOPTOSIS / CYTOPLASM / TUMOR SUPPRESSOR / VIRTUAL SCREENING / SECOND-SITE SUPPRESSOR MUTATION / COVALENT PROTEIN-RNA LINKAGE / SMALL-MOLECULE DRUG / ALTERNATIVE SPLICING / P53 DNA- BINDING DOMAIN / TRANSCRIPTION REGULATION / NUCLEAR PROTEIN / SURFACE CREVICE / DISEASE MUTATION / PROTEIN STABILIZATION / HOST-VIRUS INTERACTION / LI-FRAUMENI SYNDROME / ENDOPLASMIC RETICULUM / METAL-BINDING / ANTI-ONCOGENE / SUPERSTABLE MUTANT / DNA-BINDING PROTEIN / DNA BINDING / DNA-BINDING / POLYMORPHISM / GLYCOPROTEIN |