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TitleD-Ribose-5-Phosphate Isomerase B from Escherichia Coli is Also a Functional D-Allose-6-Phosphate Isomerase, While the Mycobacterium Tuberculosis Enzyme is not.
Journal, issue, pagesJ. Mol. Biol., Vol. 382, Page 667-, Year 2008
Publish dateJun 10, 2008 (structure data deposition date)
AuthorsRoos, A.K. / Mariano, S. / Kowalinski, E. / Salmon, L. / Mowbray, S.L.
External linksJ. Mol. Biol. / PubMed:18640127
MethodsX-ray diffraction
Resolution1.65 - 2.1 Å
Structure data

PDB-2vvo:
Crystal structure of Mycobacterium tuberculosis ribose-5-phosphate isomerase B in complex with alpha d-allose 6-phosphate
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

PDB-2vvp:
Crystal structure of Mycobacterium tuberculosis ribose-5-phosphate isomerase B in complex with its substrates ribose 5-phosphate and ribulose 5-phosphate
Method: X-RAY DIFFRACTION / Resolution: 1.65 Å

PDB-2vvq:
Crystal structure of Mycobacterium tuberculosis ribose-5-phosphate isomerase B in complex with the inhibitor 5-deoxy-5-phospho-D- ribonate
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2vvr:
Crystal structure of the H99N mutant of ribose-5-phosphate isomerase B from E. coli soaked with ribose 5-phosphate
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-A6P:
6-O-phosphono-alpha-D-allopyranose

ChemComp-HOH:
WATER

ChemComp-R5P:
RIBOSE-5-PHOSPHATE

ChemComp-5RP:
RIBULOSE-5-PHOSPHATE

ChemComp-R10:
5-O-phosphono-D-ribonic acid

ChemComp-SO4:
SULFATE ION

Source
  • mycobacterium tuberculosis (bacteria)
  • escherichia coli (E. coli)
KeywordsISOMERASE / RPIB / RV2465C / RARE SUGAR / CARBOHYDRATE METABOLISM / PENTOSE PHOSPHATE PATHWAY

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