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Structure paper

TitleStructural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.
Journal, issue, pagesJ. Mol. Biol., Vol. 381, Page 1307-1319, Year 2008
Publish dateMar 15, 2008 (structure data deposition date)
AuthorsWisniewska, M. / Goettig, P. / Maskos, K. / Belouski, E. / Winters, D. / Hecht, R. / Black, R. / Bode, W.
External linksJ. Mol. Biol. / PubMed:18638486
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-3cki:
Crystal structure of the TACE-N-TIMP-3 complex
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHydrolase / hydrolase inhibitor / extra-cellular matrix / catalytic zinc / sA-sB loop / Alternative splicing / Cleavage on pair of basic residues / Glycoprotein / Membrane / Metal-binding / Metalloprotease / Notch signaling pathway / Phosphoprotein / Protease / SH3-binding / Transmembrane / Zymogen / Disease mutation / Extracellular matrix / Metalloenzyme inhibitor / Metalloprotease inhibitor / Secreted / Sensory transduction / Vision

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