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-Structure paper
| Title | A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 51, Page 4465-4475, Year 2008 |
| Publish date | Mar 28, 2008 (structure data deposition date) |
 Authors | Rawson, T.E. / Ruth, M. / Blackwood, E. / Burdick, D. / Corson, L. / Dotson, J. / Drummond, J. / Fields, C. / Georges, G.J. / Goller, B. ...Rawson, T.E. / Ruth, M. / Blackwood, E. / Burdick, D. / Corson, L. / Dotson, J. / Drummond, J. / Fields, C. / Georges, G.J. / Goller, B. / Halladay, J. / Hunsaker, T. / Kleinheinz, T. / Krell, H.W. / Li, J. / Liang, J. / Limberg, A. / McNutt, A. / Moffat, J. / Phillips, G. / Ran, Y. / Safina, B. / Ultsch, M. / Walker, L. / Wiesmann, C. / Zhang, B. / Zhou, A. / Zhu, B.Y. / Ruger, P. / Cochran, A.G. |
 External links | J. Med. Chem. / PubMed:18630890 |
| Methods | X-ray diffraction |
| Resolution | 2.7 Å |
| Structure data |  PDB-3coh: |
| Chemicals |  ChemComp-83H: |
| Source |
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 Keywords | TRANSFERASE / Aurora-A / Inhibitor Complex / ATP-binding / Cell cycle / Kinase / Nucleotide-binding / Phosphoprotein / Serine/threonine-protein kinase |
homo sapiens (human)