+Search query
-Structure paper
Title | Effect of flap mutations on structure of HIV-1 protease and inhibition by saquinavir and darunavir. |
---|---|
Journal, issue, pages | J. Mol. Biol., Vol. 381, Page 102-115, Year 2008 |
Publish date | Apr 27, 2008 (structure data deposition date) |
Authors | Liu, F. / Kovalevsky, A.Y. / Tie, Y. / Ghosh, A.K. / Harrison, R.W. / Weber, I.T. |
External links | J. Mol. Biol. / PubMed:18597780 |
Methods | X-ray diffraction |
Resolution | 1.05 - 1.4 Å |
Structure data | PDB-3cyw: PDB-3cyx: PDB-3d1x: PDB-3d1y: PDB-3d1z: PDB-3d20: |
Chemicals | ChemComp-CL: ChemComp-017: ChemComp-GOL: ChemComp-HOH: ChemComp-ROC: ChemComp-NA: ChemComp-ACY: ChemComp-PO4: |
Source |
|
Keywords | HYDROLASE / DRUG RESISTANCE; HIV-1 / AIDS / Aspartyl protease / Capsid maturation / Capsid protein / DNA integration / DNA recombination / DNA-directed DNA polymerase / Endonuclease / Lipoprotein / Magnesium / Membrane / Metal-binding / Multifunctional enzyme / Myristate / Nuclease / Nucleotidyltransferase / Nucleus / Phosphoprotein / Protease / RNA-binding / RNA-directed DNA polymerase / Transferase / Viral nucleoprotein / Virion / Zinc-finger / HYDROLASE/HYDROLASE INHIBITOR / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / DRUG RESISTANCE / HIV-1 / I54M / Flap mutant / I54V / Darunavir |