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TitleNinety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region
Journal, issue, pagesJ. Virol., Vol. 82, Page 5869-5878, Year 2008
Publish dateOct 16, 2007 (structure data deposition date)
AuthorsKozisek, M. / Saskova, K.G. / Rezacova, P. / Brynda, J. / van Maarseveen, N.M. / De Jong, D. / Boucher, C.A. / Kagan, R.M. / Nijhuis, M. / Konvalinka, J.
External linksJ. Virol. / PubMed:18400858
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-2rkf:
HIV-1 PR resistant mutant + LPV
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2rkg:
HIV-1 PR resistant mutant + LPV
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-AB1:
N-{1-BENZYL-4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-5-PHENYL-PENTYL}-3-METHYL-2-(2-OXO-TETRAHYDRO-PYRIMIDIN-1-YL)-BUTYRAMIDE / antiretroviral, protease inhibitor*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
KeywordsHYDROLASE / resistence / insertion

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