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-Structure paper
タイトル | The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 18, Page 2959-2966, Year 2008 |
掲載日 | 2008年2月5日 (構造データの登録日) |
著者 | Tucker, T.J. / Saggar, S. / Sisko, J.T. / Tynebor, R.M. / Williams, T.M. / Felock, P.J. / Flynn, J.A. / Lai, M.T. / Liang, Y. / McGaughey, G. ...Tucker, T.J. / Saggar, S. / Sisko, J.T. / Tynebor, R.M. / Williams, T.M. / Felock, P.J. / Flynn, J.A. / Lai, M.T. / Liang, Y. / McGaughey, G. / Liu, M. / Miller, M. / Moyer, G. / Munshi, V. / Perlow-Poehnelt, R. / Prasad, S. / Sanchez, R. / Torrent, M. / Vacca, J.P. / Wan, B.L. / Yan, Y. |
リンク | Bioorg. Med. Chem. Lett. / PubMed:18396399 |
手法 | X線回折 |
解像度 | 2.7 Å |
構造データ | PDB-3c6t: PDB-3c6u: |
化合物 | ChemComp-M14: ChemComp-HOH: ChemComp-M22: |
由来 |
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キーワード | TRANSFERASE / HIV-1 reverse transcriptase / non-nucleoside inhibition / nucleotidyltrasferase / AIDS / Aspartyl protease / Capsid maturation / Capsid protein / Cytoplasm / DNA integration / DNA recombination / DNA-directed DNA polymerase / Endonuclease / Host-virus interaction / Hydrolase / Lipoprotein / Magnesium / Membrane / Metal-binding / Multifunctional enzyme / Myristate / Nuclease / Nucleotidyltransferase / Nucleus / Phosphoprotein / Protease / RNA-binding / RNA-directed DNA polymerase / Viral nucleoprotein / Virion / Zinc / Zinc-finger |