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Structure paper

TitleNADP regulates the yeast GAL induction system.
Journal, issue, pagesScience, Vol. 319, Page 1090-1092, Year 2008
Publish dateDec 30, 2007 (structure data deposition date)
AuthorsKumar, P.R. / Yu, Y. / Sternglanz, R. / Johnston, S.A. / Joshua-Tor, L.
External linksScience / PubMed:18292341
MethodsX-ray diffraction
Resolution2.1 - 2.85 Å
Structure data

PDB-3bts:
Crystal structure of a ternary complex of the transcriptional repressor Gal80p (Gal80S0 [G301R]) and the acidic activation domain of Gal4p (aa 854-874) from Saccharomyces cerevisiae with NAD
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-3btu:
Crystal structure of the super-repressor mutant of Gal80p from Saccharomyces cerevisiae; Gal80(S2) [E351K]
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

PDB-3btv:
Crystal structure of the super-repressor mutant of Gal80p from Saccharomyces cerevisiae; Gal80(S0)-[G301R]
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsTRANSCRIPTION / Eukaryotic transcription complex / NAD / Rossmann fold / Acetylation / Carbohydrate metabolism / DNA-binding / Galactose metabolism / Repressor / Transcription regulation / Activator / Metal-binding / Nucleus / Phosphoprotein / Zinc / eukaryotic transcription repressor

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