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-Structure paper
Title | Structures of Prostacyclin Synthase and Its Complexes with Substrate Analog and Inhibitor Reveal a Ligand-specific Heme Conformation Change |
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Journal, issue, pages | J. Biol. Chem., Vol. 283, Page 2917-2926, Year 2008 |
Publish date | Oct 29, 2007 (structure data deposition date) |
![]() | Li, Y.-C. / Chiang, C.-W. / Yeh, H.-C. / Hsu, P.-Y. / Whitby, F.G. / Wang, L.-H. / Chan, N.-L. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.62 - 2.5 Å |
Structure data | ![]() PDB-3b6h: ![]() PDB-3b98: ![]() PDB-3b99: |
Chemicals | ![]() ChemComp-BOG: ![]() ChemComp-MXD: ![]() ChemComp-HEM: ![]() ChemComp-HOH: ![]() ChemComp-U51: |
Source |
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![]() | ISOMERASE / prostacyclin synthase / enzyme-inhibitor complex / cyp8a1 / cytochrome p450 / Endoplasmic reticulum / Fatty acid biosynthesis / Heme / Iron / Lipid synthesis / Membrane / Metal-binding / Polymorphism / Prostaglandin biosynthesis / Transmembrane / cytochrome p450 8A1 / substrate analog-enzyme complex |