タイトル | Partial Agonists Activate PPARgamma Using a Helix 12 Independent Mechanism |
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ジャーナル・号・ページ | Structure, Vol. 15, Page 1258-1271, Year 2007 |
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掲載日 | 2007年5月31日 (構造データの登録日) |
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著者 | Bruning, J.B. / Chalmers, M.J. / Prasad, S. / Busby, S.A. / Kamenecka, T.M. / He, Y. / Nettles, K.W. / Griffin, P.R. |
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リンク | Structure / PubMed:17937915 |
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手法 | X線回折 |
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解像度 | 2.05 - 2.407 Å |
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構造データ | PDB-2q59: Crystal Structure of PPARgamma LBD bound to full agonist MRL20 手法: X-RAY DIFFRACTION / 解像度: 2.2 Å PDB-2q5p: Crystal Structure of PPARgamma bound to partial agonist MRL24 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-2q5s: Crystal Structure of PPARgamma bound to partial agonist nTZDpa 手法: X-RAY DIFFRACTION / 解像度: 2.05 Å PDB-2q61: Crystal Structure of PPARgamma ligand binding domain bound to partial agonist SR145 手法: X-RAY DIFFRACTION / 解像度: 2.197 Å PDB-2q6r: Crystal structure of PPAR gamma complexed with partial agonist SF147 手法: X-RAY DIFFRACTION / 解像度: 2.407 Å PDB-2q6s: 2.4 angstrom crystal structure of PPAR gamma complexed to BVT.13 without co-activator peptides 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å |
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化合物 | ChemComp-240: (2S)-2-(2-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID
ChemComp-241: (2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID
ChemComp-NZA: 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID / nTZDpa
ChemComp-SF1: 1-BENZYL-5-CHLORO-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
ChemComp-SF2: 5-CHLORO-1-(3-METHOXYBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
ChemComp-PLB: 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID / BVT-13
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由来 | homo sapiens (ヒト)
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キーワード | Ligand binding protein / Protein-ligand complex |
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