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Structure paper

TitleStructural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch.
Journal, issue, pagesJ. Biol. Chem., Vol. 282, Page 35814-35820, Year 2007
Publish dateFeb 22, 2007 (structure data deposition date)
AuthorsGarlatti, V. / Martin, L. / Gout, E. / Reiser, J.B. / Fujita, T. / Arlaud, G.J. / Thielens, N.M. / Gaboriaud, C.
External linksJ. Biol. Chem. / PubMed:17897951
MethodsX-ray diffraction
Resolution1.52 - 1.8 Å
Structure data

PDB-2jhh:
Structure of globular heads of M-ficolin at acidic pH
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-2jhi:
Structure of globular heads of M-ficolin complexed with N-acetyl-D- galactosamine
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2jhk:
Structure of globular heads of M-ficolin complexed with N-acetyl-D- glucosamine
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-2jhl:
Structure of globular heads of M-ficolin complexed with sialic acid
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

PDB-2jhm:
Structure of globular heads of M-ficolin at neutral pH
Method: X-RAY DIFFRACTION / Resolution: 1.52 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-A2G:
2-acetamido-2-deoxy-alpha-D-galactopyranose

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SLB:
N-acetyl-beta-neuraminic acid

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

Source
  • homo sapiens (human)
KeywordsSUGAR BINDING PROTEIN / LECTIN / COLLAGEN / ACIDIC PH / COMPLEMENT / SUGAR-BINDING PROTEIN / GLYCOPROTEIN / POLYMORPHISM / INNATE IMMUNITY

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