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TitleNew insight into the mechanism of action of and resistance to isoniazid: interaction of Mycobacterium tuberculosis enoyl-ACP reductase with INH-NADP
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 129, Page 9582-9583, Year 2007
Publish dateMay 3, 2007 (structure data deposition date)
AuthorsArgyrou, A. / Vetting, M.W. / Blanchard, J.S.
External linksJ. Am. Chem. Soc. / PubMed:17636923
MethodsX-ray diffraction
Resolution2.5 Å
Structure data

PDB-2pr2:
Structure of Mycobacterium tuberculosis enoyl-ACP reductase with bound INH-NADP.
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

Chemicals

ChemComp-DG1:
(4S)-ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE

ChemComp-HOH:
WATER

Source
  • mycobacterium tuberculosis (bacteria)
KeywordsOXIDOREDUCTASE / drug target of isoniazid

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