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Structure paper

TitleStructural insight into the altered substrate specificity of human cytochrome P450 2A6 mutants.
Journal, issue, pagesArch. Biochem. Biophys., Vol. 464, Page 197-206, Year 2007
Publish dateApr 6, 2007 (structure data deposition date)
AuthorsSansen, S. / Hsu, M.H. / Stout, C.D. / Johnson, E.F.
External linksArch. Biochem. Biophys. / PubMed:17540336
MethodsX-ray diffraction
Resolution1.95 - 2.8 Å
Structure data

PDB-2pg5:
Crystal Structure of Human Microsomal P450 2A6 N297Q
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-2pg6:
Crystal Structure of Human Microsomal P450 2A6 L240C/N297Q
Method: X-RAY DIFFRACTION / Resolution: 2.53 Å

PDB-2pg7:
Crystal Structure of Human Microsomal P450 2A6 N297Q/I300V
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / CYP2A6 / P450 2A6 / P450 / Monooxygenases / drug metabolizing enzyme / heme / mutant / indole

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