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Structure paper

TitleCutting Edge: IL-1 Receptor-Associated Kinase 4 Structures Reveal Novel Features and Multiple Conformations.
Journal, issue, pagesJ. Immunol., Vol. 178, Page 2641-2645, Year 2007
Publish dateJan 10, 2007 (structure data deposition date)
AuthorsKuglstatter, A. / Villasenor, A.G. / Shaw, D. / Lee, S.W. / Tsing, S. / Niu, L. / Song, K.W. / Barnett, J.W. / Browner, M.F.
External linksPubMed:17312103
MethodsX-ray diffraction
Resolution2 - 2.4 Å
Structure data

PDB-2oib:
Crystal structure of IRAK4 kinase domain apo form
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2oic:
Crystal structure of IRAK4 kinase domain complexed with staurosporine
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-2oid:
Crystal structure of IRAK4 kinase domain complexed with AMPPNP
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-STU:
STAUROSPORINE / anticancer, antifungal, antibiotic, alkaloid*YM

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / KINASE / HELIC C

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