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Structure paper

TitleClavulanic Acid Dehydrogenase: Structural and Biochemical Analysis of the Final Step in the Biosynthesis of the Beta-Lactamase Inhibitor Clavulanic Acid
Journal, issue, pagesBiochemistry, Vol. 46, Page 1523-, Year 2007
Publish dateNov 28, 2006 (structure data deposition date)
AuthorsMackenzie, A.K. / Kershaw, N.J. / Hernandez, H. / Robinson, C.V. / Schofield, C.J. / Andersson, I.
External linksBiochemistry / PubMed:17279617
MethodsX-ray diffraction
Resolution1.8 - 2.1 Å
Structure data

PDB-2jah:
Biochemical and structural analysis of the Clavulanic acid dehydeogenase (CAD) from Streptomyces clavuligerus
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-2jap:
Clavulanic Acid Dehydrogenase: Structural and Biochemical Analysis of the Final Step in the Biosynthesis of the beta-Lactamase Inhibitor Clavulanic acid
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-NDP:
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-HOH:
WATER

ChemComp-J01:
(2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID / antibiotic, inhibitor*YM

Source
  • streptomyces clavuligerus (bacteria)
KeywordsOXIDOREDUCTASE / SHORT-CHAIN DEHYDROGENASE/REDUCTASE / LACTAMASE INHIBITOR / ANTIBIOTIC BIOSYNTHESIS / NADPH / CLAVULANIC ACID / BETA-LACTAMASE INHIBITOR

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