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TitleCrystal Structures of a Bacterial 6-Phosphogluconate Dehydrogenase Reveal Aspects of Specificity, Mechanism and Mode of Inhibition by Analogues of High-Energy Reaction Intermediates.
Journal, issue, pagesFEBS J., Vol. 274, Page 275-, Year 2007
Publish dateJul 21, 2006 (structure data deposition date)
AuthorsSundaramoorthy, R. / Iulek, J. / Barrett, M.P. / Bidet, O. / Ruda, G.F. / Gilbert, I.H. / Hunter, W.N.
External linksFEBS J. / PubMed:17222187
MethodsX-ray diffraction
Resolution2.3 - 2.79 Å
Structure data

PDB-2iyo:
Structural characterization of a bacterial 6PDH reveals aspects of specificity, mechanism and mode of inhibition
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-2iyp:
product rup
Method: X-RAY DIFFRACTION / Resolution: 2.79 Å

PDB-2iz0:
PEX inhibitor-home data
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

PDB-2iz1:
6PDH complexed with PEX inhibitor synchrotron data
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-6PG:
6-PHOSPHOGLUCONIC ACID / 6-Phosphogluconic acid

ChemComp-CAC:
CACODYLATE ION / Cacodylic acid

ChemComp-HOH:
WATER / Water

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Nicotinamide adenine dinucleotide phosphate

ChemComp-5RP:
RIBULOSE-5-PHOSPHATE / Ribulose 5-phosphate

ChemComp-A2P:
ADENOSINE-2'-5'-DIPHOSPHATE / Adenosine diphosphate

ChemComp-RES:
4-PHOSPHO-D-ERYTHRONOHYDROXAMIC ACID

ChemComp-GOL:
GLYCEROL / Glycerol

ChemComp-P33:
3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL / precipitant*YM / Polyethylene glycol

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER / Diethylene glycol

ChemComp-ATR:
2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE

ChemComp-CL:
Unknown entry / Chloride

ChemComp-EDO:
1,2-ETHANEDIOL / Ethylene glycol

Source
  • lactococcus lactis (lactic acid bacteria)
KeywordsOXIDOREDUCTASE / 6-PHOSPHOGLUCONATE DEHYDROGENASE / NADP / PENTOSE SHUNT / GLUCONATE UTILIZATION / PENTOSE PHOSPHATE PATHWAY

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