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TitleDesign and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 17, Page 937-941, Year 2007
Publish dateOct 26, 2006 (structure data deposition date)
AuthorsHan, H.O. / Kim, S.H. / Kim, K.H. / Hur, G.C. / Yim, H.J. / Chung, H.K. / Woo, S.H. / Koo, K.D. / Lee, C.S. / Koh, J.S. / Kim, G.T.
External linksBioorg. Med. Chem. Lett. / PubMed:17157019
MethodsX-ray diffraction
Resolution2.3 Å
Structure data

PDB-2npa:
the crystal structure of the human PPARaplpha ligand binding domain in complex with a a-hydroxyimino phenylpropanoic acid
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-MMB:
(2R,3E)-2-{4-[(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHOXY]BENZYL}-3-(PROPOXYIMINO)BUTANOIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / protein-agonist complex

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