タイトル | Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors. |
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ジャーナル・号・ページ | Proteins, Vol. 66, Page 538-546, Year 2007 |
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掲載日 | 2006年3月23日 (構造データの登録日) |
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著者 | Evdokimov, A.G. / Pokross, M. / Walter, R.L. / Mekel, M. / Barnett, B.L. / Amburgey, J. / Seibel, W.L. / Soper, S.J. / Djung, J.F. / Fairweather, N. ...Evdokimov, A.G. / Pokross, M. / Walter, R.L. / Mekel, M. / Barnett, B.L. / Amburgey, J. / Seibel, W.L. / Soper, S.J. / Djung, J.F. / Fairweather, N. / Diven, C. / Rastogi, V. / Grinius, L. / Klanke, C. / Siehnel, R. / Twinem, T. / Andrews, R. / Curnow, A. |
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リンク | Proteins / PubMed:17120228 |
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手法 | X線回折 |
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解像度 | 1 - 2.13 Å |
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構造データ | PDB-2gg0: Novel bacterial methionine aminopeptidase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.28 Å PDB-2gg2: Novel bacterial methionine aminopeptidase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.0 Å PDB-2gg3: Novel bacterial methionine aminopeptidase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-2gg5: Novel bacterial methionine aminopeptidase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.12 Å PDB-2gg7: Novel bacterial methionine aminopeptidase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.12 Å PDB-2gg8: Novel bacterial methionine aminopeptidase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-2gg9: Novel bacterial methionine aminopeptidase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.05 Å PDB-2ggb: Novel bacterial methionine aminopeptidase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 2.13 Å PDB-2ggc: Novel bacterial methionine aminopeptidase inhibitors 手法: X-RAY DIFFRACTION / 解像度: 1.0 Å |
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化合物 | ChemComp-U11: METHYL N-{(2S,3R)-3-AMINO-2-HYDROXY-3-[4-(TRIFLUOROMETHYL)PHENYL]PROPANOYL}ALANYLGLYCINATE
ChemComp-U12: 5-IMINO-4-(3-TRIFLUOROMETHYL-PHENYLAZO)-5H-PYRAZOL-3-YLAMINE
ChemComp-U13: 4-(4-FLUORO-PHENYLAZO)-5-IMINO-5H-PYRAZOL-3-YLAMINE
ChemComp-U19: 5-IMINO-4-(2-TRIFLUOROMETHYL-PHENYLAZO)-5H-PYRAZOL-3-YLAMINE
ChemComp-U14: 3-(5-AMINO-3-IMINO-3H-PYRAZOL-4-YLAZO)-BENZOIC ACID
ChemComp-U15: METHYL N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-METHYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE
ChemComp-U16: METHYL N-[(2S,3R)-3-AMINO-2-HYDROXY-3-(4-ISOPROPYLPHENYL)PROPANOYL]-D-ALANYL-D-LEUCINATE
ChemComp-U17: METHYL N-[(2S,3R)-3-AMINO-2-HYDROXYHEPTANOYL]-L-SERYL-L-LEUCINATE
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由来 | - escherichia coli k12 (大腸菌)
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キーワード | HYDROLASE / methionine amino peptidase / pita-bread fold / MAP inhibitor / antibacterial |
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