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TitleN-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor.
Journal, issue, pagesJ. Med. Chem., Vol. 49, Page 6465-6488, Year 2006
Publish dateJun 7, 2006 (structure data deposition date)
AuthorsHennequin, L.F. / Allen, J. / Breed, J. / Curwen, J. / Fennell, M. / Green, T.P. / Lambert-van der Brempt, C. / Morgentin, R. / Norman, R.A. / Olivier, A. ...Hennequin, L.F. / Allen, J. / Breed, J. / Curwen, J. / Fennell, M. / Green, T.P. / Lambert-van der Brempt, C. / Morgentin, R. / Norman, R.A. / Olivier, A. / Otterbein, L. / Ple, P.A. / Warin, N. / Costello, G.
External linksJ. Med. Chem. / PubMed:17064066
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2h8h:
Src kinase in complex with a quinazoline inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-H8H:
N-(5-CHLORO-1,3-BENZODIOXOL-4-YL)-7-[2-(4-METHYLPIPERAZIN-1-YL)ETHOXY]-5-(TETRAHYDRO-2H-PYRAN-4-YLOXY)QUINAZOLIN-4-AMINE / inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SRC KINASE

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