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| Title | Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme. |
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| Journal, issue, pages | J. Mol. Biol., Vol. 364, Page 747-763, Year 2006 |
| Publish date | Jun 20, 2006 (structure data deposition date) |
Authors | Faucher, F. / Pereira de Jesus-Tran, K. / Cantin, L. / Luu-The, V. / Labrie, F. / Breton, R. |
External links | J. Mol. Biol. / PubMed:17034817 |
| Methods | X-ray diffraction |
| Resolution | 1.35 - 2.9 Å |
| Structure data | ![]() PDB-2hdj: ![]() PDB-2he5: ![]() PDB-2he8: ![]() PDB-2hej: |
| Chemicals | ![]() ChemComp-SO4: ![]() ChemComp-NDP: ![]() ChemComp-EDO: ![]() ChemComp-HOH: ![]() ChemComp-ACT: ![]() ChemComp-BME: ![]() ChemComp-GOL: ![]() ChemComp-MPD: |
| Source |
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Keywords | OXIDOREDUCTASE / HUMAN 3ALPHAHDS3 / ALDO-KETO REDUCTASE / NADPH / AKR / AKR1C2 / 17a-HSD / AKR1C21 / HSD / hydroxysteroid dehydrogenase / open conformation / apo-form / closed conformation |
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homo sapiens (human)
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