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Structure paper

TitleCrystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 35478-35486, Year 2006
Publish dateApr 16, 2004 (structure data deposition date)
AuthorsJohnson, D.J.D. / Langdown, J. / Li, W. / Luis, S.A. / Baglin, T.P. / Huntington, J.A.
External linksJ. Biol. Chem. / PubMed:16973611
MethodsX-ray diffraction
Resolution2.1 - 2.75 Å
Structure data

PDB-1t1f:
Crystal Structure of Native Antithrombin in its Monomeric Form
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

PDB-2b5t:
2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2beh:
Crystal structure of antithrombin variant S137A/V317C/T401C with plasma latent antithrombin
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-IOD:
IODIDE ION

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
KeywordsBLOOD CLOTTING / serine-cysteine proteinase inhibitor; thrombin; human; x-ray crystallography / Blood coagulation / antithrombin dimer

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