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-Structure paper
Title | Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate |
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Journal, issue, pages | Mol. Microbiol., Vol. 61, Page 1457-, Year 2006 |
Publish date | Nov 29, 2005 (structure data deposition date) |
![]() | Dawson, A. / Gibellini, F. / Sienkiewicz, N. / Tulloch, L.B. / Fyfe, P.K. / Mcluskey, K. / Fairlamb, A.H. / Hunter, W.N. |
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Methods | X-ray diffraction |
Resolution | 2.2 Å |
Structure data | ![]() PDB-2c7v: |
Chemicals | ![]() ChemComp-NAP: ![]() ChemComp-MTX: ![]() ChemComp-NI: ![]() ChemComp-ACT: ![]() ChemComp-HOH: |
Source |
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![]() | OXIDOREDUCTASE / PTERIDINE REDUCTASE / TRYPANOSOMATIDS / DRUG RESISTANCE / SHORT-CHAIN DEHYDROGENASE/REDUCTASE / METHOTREXATE RESISTANCE |