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TitleStructure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition by the Archetypal Antifolate Methotrexate
Journal, issue, pagesMol. Microbiol., Vol. 61, Page 1457-, Year 2006
Publish dateNov 29, 2005 (structure data deposition date)
AuthorsDawson, A. / Gibellini, F. / Sienkiewicz, N. / Tulloch, L.B. / Fyfe, P.K. / Mcluskey, K. / Fairlamb, A.H. / Hunter, W.N.
External linksMol. Microbiol. / PubMed:16968221
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2c7v:
Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-MTX:
METHOTREXATE

ChemComp-NI:
NICKEL (II) ION

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • trypanosoma brucei brucei (eukaryote)
KeywordsOXIDOREDUCTASE / PTERIDINE REDUCTASE / TRYPANOSOMATIDS / DRUG RESISTANCE / SHORT-CHAIN DEHYDROGENASE/REDUCTASE / METHOTREXATE RESISTANCE

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