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TitleStructure of the Y94F mutant of Escherichia coli thymidylate synthase.
Journal, issue, pagesACTA CRYSTALLOGR. ,SECT. F, Vol. 62, Page 840-843, Year 2006
Publish dateJan 24, 2006 (structure data deposition date)
AuthorsRoberts, S.A. / Hyatt, D.C. / Honts, J.E. / Changchien, L. / Maley, G.F. / Maley, F. / Montfort, W.R.
External linksACTA CRYSTALLOGR. ,SECT. F / PubMed:16946460
MethodsX-ray diffraction
Resolution1.6 - 2 Å
Structure data

PDB-2ftn:
E. coli thymidylate synthase Y94F mutant
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-2fto:
Y94F mutant of thymidylate synthase bound to thymidine-5'-phosphate and 10-propargyl-5,8-dideazafolid acid
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

ChemComp-TMP:
THYMIDINE-5'-PHOSPHATE

ChemComp-CB3:
10-PROPARGYL-5,8-DIDEAZAFOLIC ACID

Source
  • escherichia coli (E. coli)
KeywordsTRANSFERASE / methyltransferase

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