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TitleThe first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.
Journal, issue, pagesProc. Natl. Acad. Sci. Usa, Vol. 103, Page 12429-12434, Year 2006
Publish dateJul 19, 2006 (structure data deposition date)
AuthorsLou, M. / Garrett, T.P. / McKern, N.M. / Hoyne, P.A. / Epa, V.C. / Bentley, J.D. / Lovrecz, G.O. / Cosgrove, L.J. / Frenkel, M.J. / Ward, C.W.
External linksProc. Natl. Acad. Sci. Usa / PubMed:16894147
MethodsX-ray diffraction
Resolution2.32 Å
Structure data

PDB-2hr7:
Insulin receptor (domains 1-3)
Method: X-RAY DIFFRACTION / Resolution: 2.32 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-P33:
3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL / precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / HORMONE RECEPTOR / LEUCINE RICH REPEAT

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