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Structure paper

TitleDomain-swapped structure of the potent antiviral protein griffithsin and its mode of carbohydrate binding.
Journal, issue, pagesStructure, Vol. 14, Page 1127-1135, Year 2006
Publish dateApr 28, 2006 (structure data deposition date)
AuthorsZiolkowska, N.E. / O'keefe, B.R. / Mori, T. / Zhu, C. / Giomarelli, B. / Vojdani, F. / Palmer, K.E. / McMahon, J.B. / Wlodawer, A.
External linksStructure / PubMed:16843894
MethodsX-ray diffraction
Resolution0.94 - 2.02 Å
Structure data

PDB-2gty:
Crystal structure of unliganded griffithsin
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-2guc:
Crystal structure of a complex of griffithsin with mannose at 1.78 A resolution.
Method: X-RAY DIFFRACTION / Resolution: 1.79 Å

PDB-2gud:
Crystal structure of a complex of griffithsin with mannose at 0.94 A resolution
Method: X-RAY DIFFRACTION / Resolution: 0.94 Å

PDB-2gue:
Crystal structure of a complex of griffithsin with N-acetylglucosamine
Method: X-RAY DIFFRACTION / Resolution: 2.02 Å

PDB-2gux:
Selenomethionine derivative of griffithsin
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-BMA:
beta-D-mannopyranose

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • griffithsia (eukaryote)
KeywordsSUGAR BINDING PROTEIN / griffithsin / lectins / domain swapping / mannose binding / HIV / SARS

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