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TitleDiscovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: synthesis and SAR studies
Journal, issue, pagesBioorg. Med. Chem. Lett., Vol. 16, Page 4163-4168, Year 2006
Publish dateApr 28, 2006 (structure data deposition date)
AuthorsLin, X. / Murray, J.M. / Rico, A.C. / Wang, M.X. / Chu, D.T. / Zhou, Y. / Del Rosario, M. / Kaufman, S. / Ma, S. / Fang, E. ...Lin, X. / Murray, J.M. / Rico, A.C. / Wang, M.X. / Chu, D.T. / Zhou, Y. / Del Rosario, M. / Kaufman, S. / Ma, S. / Fang, E. / Crawford, K. / Jefferson, A.B.
External linksBioorg. Med. Chem. Lett. / PubMed:16765046
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-2gu8:
Discovery of 2-Pyrimidyl-5-Amidothiophenes as Novel and Potent Inhibitors for AKT: Synthesis and SAR Studies
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-796:
N-[(1S)-2-AMINO-1-(2,4-DICHLOROBENZYL)ETHYL]-5-[2-(METHYLAMINO)PYRIMIDIN-4-YL]THIOPHENE-2-CARBOXAMIDE

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / TRANSFERASE/INHIBITOR / CAMP-dependent protein kinase / PKA / Akt / Kinase / Drug Design / ternary complex / TRANSFERASE-INHIBITOR COMPLEX

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