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Structure paper

TitleTargeting the dimerization initiation site of HIV-1 RNA with aminoglycosides: from crystal to cell.
Journal, issue, pagesNucleic Acids Res., Vol. 34, Page 2328-2339, Year 2006
Publish dateDec 13, 2005 (structure data deposition date)
AuthorsEnnifar, E. / Paillart, J.C. / Bodlenner, A. / Walter, P. / Weibel, J.-M. / Aubertin, A.-M. / Pale, P. / Dumas, P. / Marquet, R.
External linksNucleic Acids Res. / PubMed:16679451
MethodsX-ray diffraction
Resolution1.8 - 2.2 Å
Structure data

PDB-2fcx:
HIV-1 DIS kissing-loop in complex with neamine
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-2fcy:
HIV-1 DIS kissing-loop in complex with Neomycin
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-2fcz:
HIV-1 DIS kissing-loop in complex with ribostamycin
Method: X-RAY DIFFRACTION / Resolution: 2.01 Å

PDB-2fd0:
HIV-1 DIS kissing-loop in complex with lividomycin
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-XXX:
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside / antibiotic*YM

ChemComp-HOH:
WATER

ChemComp-NMY:
NEOMYCIN / antibiotic*YM

ChemComp-SO4:
SULFATE ION

ChemComp-RIO:
RIBOSTAMYCIN / antibiotic*YM

ChemComp-LIV:
(2R,3S,4S,5S,6R)-2-((2S,3S,4R,5R,6R)-5-AMINO-2-(AMINOMETHYL)-6-((2R,3S,4R,5S)-5-((1R,2R,3S,5R,6S)-3,5-DIAMINO-2-((2S,3R / antibiotic*YM

KeywordsRNA / HIV-1 / aminoglycoside / antibiotics

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