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Structure paper

TitleStructure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning.
Journal, issue, pagesJ. Biol. Chem., Vol. 281, Page 20521-20529, Year 2006
Publish dateOct 20, 2005 (structure data deposition date)
AuthorsBitto, E. / Bingman, C.A. / Wesenberg, G.E. / McCoy, J.G. / Phillips, G.N.
External linksJ. Biol. Chem. / PubMed:16672222
MethodsX-ray diffraction
Resolution2.1 - 2.35 Å
Structure data

PDB-2bdu:
X-Ray Structure of a Cytosolic 5'-Nucleotidase III from Mus Musculus MM.158936
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-2g06:
X-ray structure of mouse pyrimidine 5'-nucleotidase type 1, with bound magnesium(II)
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-2g07:
X-ray structure of mouse pyrimidine 5'-nucleotidase type 1, phospho-enzyme intermediate analog with Beryllium fluoride
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-2g08:
X-ray structure of mouse pyrimidine 5'-nucleotidase type 1, product-transition complex analog with Aluminum fluoride
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-2g09:
X-ray structure of mouse pyrimidine 5'-nucleotidase type 1, product complex
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-2g0a:
X-ray structure of mouse pyrimidine 5'-nucleotidase type 1 with lead(II) bound in active site
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-MG:
Unknown entry

ChemComp-PIN:
PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID) / pH buffer*YM

ChemComp-AF3:
ALUMINUM FLUORIDE

ChemComp-PO4:
PHOSPHATE ION

ChemComp-PB:
LEAD (II) ION

Source
  • mus musculus (house mouse)
KeywordsHYDROLASE / UMPH-1 / CYTOSOLIC 5'-NUCLEOTIDASE III / NT5C3 PROTEIN / AAH38029 / BC038029 / MM.158936 / STRUCTURAL GENOMICS / PROTEIN STRUCTURE INITIATIVE / PSI / CENTER FOR EUKARYOTIC STRUCTURAL GENOMICS / CESG / UniProt Q9D020 / Pyrimidine 5'-nucleotidase 1 / P5n-1 / Lead Poisoning / STRUCTURAL GENOMICS FUNCTIONAL FOLLOW-UP STUDY

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