タイトル | Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site |
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ジャーナル・号・ページ | Chem. Biol., Vol. 13, Page 129-138, Year 2006 |
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掲載日 | 2005年11月24日 (構造データの登録日) |
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著者 | Murray, J.B. / Meroueh, S.O. / Russell, R.J. / Lentzen, G. / Haddad, J. / Mobashery, S. |
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リンク | Chem. Biol. / PubMed:16492561 |
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手法 | X線回折 |
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解像度 | 2.6 - 3.8 Å |
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構造データ | PDB-2f4s: A-site RNA in complex with neamine 手法: X-RAY DIFFRACTION / 解像度: 2.8 Å PDB-2f4t: Asite RNA + designer antibiotic 手法: X-RAY DIFFRACTION / 解像度: 3 Å PDB-2f4u: Asite RNA + designer antibiotic 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-2f4v: 30S ribosome + designer antibiotic 手法: X-RAY DIFFRACTION / 解像度: 3.8 Å |
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化合物 | ChemComp-XXX: (1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside / ネアミン / 抗生剤*YM
ChemComp-AB9: (2R)-4-AMINO-N-{(1R,2S,3R,4R,5S)-5-AMINO-2-{2-[(2-AMINOETHYL)AMINO]ETHOXY}-4-[(2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-3-HYDROXYCYCLOHEXYL}-2-HYDROXYBUTANAMIDE
ChemComp-AB6: (2R)-4-AMINO-N-((1R,2S,3R,4R,5S)-5-AMINO-4-[(2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-{2-[(3-AMINOPROPYL)AMINO]ETHOXY}-3-HYDROXYCYCLOHEXYL)-2-HYDROXYBUTANAMIDE
ChemComp-D2C: (2S,4S,4AR,5AS,6S,11R,11AS,12R,12AR)-7-CHLORO-4-(DIMETHYLAMINO)-6,10,11,12-TETRAHYDROXY-1,3-DIOXO-1,2,3,4,4A,5,5A,6,11,11A,12,12A-DODECAHYDROTETRACENE-2-CARBOXAMIDE
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由来 | ![](img/tx_bacteria.gif) thermus thermophilus (バクテリア)
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キーワード | RNA / A-site RNA / neamine / Asite RNA / designer antibiotic / RIBOSOME / 30S ribosome subunit |
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