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Structure paper

TitleProstaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost.
Journal, issue, pagesBiochemistry, Vol. 45, Page 1987-1996, Year 2006
Publish dateNov 18, 2005 (structure data deposition date)
AuthorsKomoto, J. / Yamada, T. / Watanabe, K. / Woodward, D.F. / Takusagawa, F.
External linksBiochemistry / PubMed:16475787
MethodsX-ray diffraction
Resolution2 Å
Structure data

PDB-2f38:
Crystal structure of prostaglandin F synathase containing bimatoprost
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-NAP:
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE

ChemComp-15M:
(5Z)-7-{(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3S)-3-HYDROXY-5-PHENYLPENT-1-ENYL]CYCLOPENTYL}-N-ETHYLHEPT-5-ENAMIDE / medication*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsOXIDOREDUCTASE / Prostaglandin F synthase / AKR1C3 / PGF2alpha fromation / PGH2 / bimatoprost / catalytic mechanism

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