タイトル | Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection. |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 16, Page 118-, Year 2006 |
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掲載日 | 2005年9月3日 (構造データの登録日) |
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著者 | Burchat, A. / Borhani, D.W. / Calderwood, D.J. / Hirst, G.C. / Li, B. / Stachlewitz, R.F. |
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リンク | Bioorg. Med. Chem. Lett. / PubMed:16216497 |
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手法 | X線回折 |
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解像度 | 2.15 - 2.85 Å |
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構造データ | PDB-2c0i: Src family kinase Hck with bound inhibitor A-420983 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-2c0o: Src family kinase Hck with bound inhibitor A-770041 手法: X-RAY DIFFRACTION / 解像度: 2.85 Å PDB-2c0t: Src family kinase Hck with bound inhibitor A-641359 手法: X-RAY DIFFRACTION / 解像度: 2.15 Å |
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化合物 | ChemComp-L1G: N-(4-{4-AMINO-1-[4-(4-METHYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE
ChemComp-L2G: N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE
ChemComp-L3G: N-(4-{4-AMINO-1-[1-(TETRAHYDRO-2H-PYRAN-4-YL)PIPERIDIN-4-YL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE
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由来 | homo sapiens (ヒト)
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キーワード | TRANSFERASE / TYROSINE-PROTEIN KINASE / ATP-BINDING / KINASE / LIPOPROTEIN / MYRISTATE / NUCLEOTIDE-BINDING / PALMITATE / PHOSPHORYLATION / SH2 DOMAIN / SH3 DOMAIN |
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