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TitleAntigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH.
Journal, issue, pagesJ. Mol. Biol., Vol. 350, Page 112-125, Year 2005
Publish dateDec 22, 2004 (structure data deposition date)
AuthorsConrath, K. / Vincke, C. / Stijlemans, B. / Schymkowitz, J. / Decanniere, K. / Wyns, L. / Muyldermans, S. / Loris, R.
External linksJ. Mol. Biol. / PubMed:15913651
MethodsX-ray diffraction
Resolution1.6 - 2.7 Å
Structure data

PDB-1yc7:
cAbAn33 VHH fragment against VSG
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-1yc8:
cAbAn33- Y37V/E44G/R45L triple mutant
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-1yzz:
Humanized caban33 at room temperature
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • camelus dromedarius (Arabian camel)
KeywordsIMMUNE SYSTEM / antibody / camel antibody / UNKNOWN FUNCTION / humanization

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