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Structure paper

TitleStructural basis for the inhibition of mammalian membrane adenylyl cyclase by 2 '(3')-O-(N-Methylanthraniloyl)-guanosine 5 '-triphosphate.
Journal, issue, pagesJ. Biol. Chem., Vol. 280, Page 7253-7261, Year 2005
Publish dateJun 9, 2004 (structure data deposition date)
AuthorsMou, T.C. / Gille, A. / Fancy, D.A. / Seifert, R. / Sprang, S.R.
External linksJ. Biol. Chem. / PubMed:15591060
MethodsX-ray diffraction
Resolution2.8 - 2.9 Å
Structure data

PDB-1tl7:
Complex Of Gs- With The Catalytic Domains Of Mammalian Adenylyl Cyclase: Complex With 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-triphosphate and Mn
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-1u0h:
STRUCTURAL BASIS FOR THE INHIBITION OF MAMMALIAN ADENYLYL CYCLASE BY MANT-GTP
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-FOK:
FORSKOLIN

ChemComp-ONM:
3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATE

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-GSP:
5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE

ChemComp-HOH:
WATER

Source
  • canis lupus familiaris (dog)
  • rattus norvegicus (Norway rat)
  • bos taurus (cattle)
KeywordsLYASE / adenylyl cyclase / Gsa / MANT-GTP

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