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Structure paper

TitleThe X-ray structure of RANTES: heparin-derived disaccharides allows the rational design of chemokine inhibitors.
Journal, issue, pagesStructure, Vol. 12, Page 2081-2093, Year 2004
Publish dateJul 26, 2004 (structure data deposition date)
AuthorsShaw, J.P. / Johnson, Z. / Borlat, F. / Zwahlen, C. / Kungl, A. / Roulin, K. / Harrenga, A. / Wells, T.N. / Proudfoot, A.E.
External linksStructure / PubMed:15530372
MethodsX-ray diffraction
Resolution1.7 - 2.2 Å
Structure data

PDB-1u4l:
human RANTES complexed to heparin-derived disaccharide I-S
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1u4m:
human RANTES complexed to heparin-derived disaccharide III-S
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1u4p:
Crystal Structure of human RANTES mutant K45E
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-1u4r:
Crystal Structure of human RANTES mutant 44-AANA-47
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-ACY:
ACETIC ACID

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsATTRACTANT / CHEMOATTRACTANT / CYTOKINE / CHEMOKINE / RANTES / GLYCOSAMINOGLYCAN / PROTEIN-HEPARIN DISACCHARIDE COMPLEX / MUTANT

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