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-Structure paper
Title | Crystal Structures of Calpain-E64 and -Leupeptin Inhibitor Complexes Reveal Mobile Loops Gating the Active Site |
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Journal, issue, pages | J. Mol. Biol., Vol. 343, Page 1313-1326, Year 2004 |
Publish date | Jun 9, 2004 (structure data deposition date) |
Authors | Moldoveanu, T. / Campbell, R.L. / Cuerrier, D. / Davies, P.L. |
External links | J. Mol. Biol. / PubMed:15491615 |
Methods | X-ray diffraction |
Resolution | 1.8 - 1.9 Å |
Structure data | PDB-1tl9: PDB-1tlo: |
Chemicals | ChemComp-CA: ChemComp-HOH: ChemComp-E64: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / Covalently-linked inhibitor at the active site cysteine forms a hemithioacetal / hydrolase / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / covalently-linked inhibitor at the active site (cysteine 115) forms a thioester |