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Structure paper

TitleStructural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 101, Page 2706-2711, Year 2004
Publish dateDec 24, 2003 (structure data deposition date)
AuthorsHuang, C.C. / Venturi, M. / Majeed, S. / Moore, M.J. / Phogat, S. / Zhang, M.-Y. / Dimitrov, D.S. / Hendrickson, W.A. / Robinson, J. / Sodroski, J. ...Huang, C.C. / Venturi, M. / Majeed, S. / Moore, M.J. / Phogat, S. / Zhang, M.-Y. / Dimitrov, D.S. / Hendrickson, W.A. / Robinson, J. / Sodroski, J. / Wyatt, R. / Choe, H. / Farzan, M. / Kwong, P.D.
External linksProc. Natl. Acad. Sci. USA / PubMed:14981267
MethodsX-ray diffraction
Resolution1.7 - 2.9 Å
Structure data

PDB-1rz7:
CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 48D
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1rz8:
CRYSTAL STRUCTURE OF HUMAN ANTI-HIV-1 GP120-REACTIVE ANTIBODY 17B
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1rzf:
Crystal structure of Human anti-HIV-1 GP120-reactive antibody E51
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-1rzg:
Crystal structure of Human anti-HIV-1 GP120 reactive antibody 412d
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-1rzi:
Crystal structure of human anti-HIV-1 gp120-reactive antibody 47e fab
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-1rzj:
HIV-1 HXBC2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-1rzk:
HIV-1 YU2 GP120 ENVELOPE GLYCOPROTEIN COMPLEXED WITH CD4 AND INDUCED NEUTRALIZING ANTIBODY 17B
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-CYS:
CYSTEINE

ChemComp-ASP:
ASPARTIC ACID

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • human immunodeficiency virus 1
KeywordsIMMUNE SYSTEM / HIV-1; gp120; CD4i; antibodies; tyrosine sulfation; VH-gene usage / Viral protein/Immune system / COMPLEX (HIV ENVELOPE PROTEIN-CD4-FAB); HIV-1 EXTERIOR ENVELOPE GP120 FROM LABORATORY-ADAPTED ISOLATE; HXBC2; SURFACE T-CELL GLYCOPROTEIN CD4; ANTIGEN-BINDING FRAGMENT OF HUMAN IMMUNOGLOBULIN 17B / Viral protein-Immune system COMPLEX

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