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Structure paper

TitleStructural basis for dipeptide amide isoform-selective inhibition of neuronal nitric oxide synthase.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 11, Page 54-59, Year 2004
Publish dateApr 29, 2003 (structure data deposition date)
AuthorsFlinspach, M.L. / Li, H. / Jamal, J. / Yang, W. / Huang, H. / Hah, J.M. / Gomez-Vidal, J.A. / Litzinger, E.A. / Silverman, R.B. / Poulos, T.L.
External linksNat. Struct. Mol. Biol. / PubMed:14718923
MethodsX-ray diffraction
Resolution1.74 - 2.5 Å
Structure data

PDB-1p6h:
Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-1p6i:
Rat neuronal NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-1p6j:
Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound
Method: X-RAY DIFFRACTION / Resolution: 2.0 Å

PDB-1p6k:
Rat neuronal NOS D597N mutant heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound
Method: X-RAY DIFFRACTION / Resolution: 1.78 Å

PDB-1p6l:
Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-2,4-L-diaminobutyric amide bound
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-1p6m:
Bovine endothelial NOS heme domain with (4S)-N-(4-amino-5-[aminoethyl]aminopentyl)-N'-nitroguanidine bound
Method: X-RAY DIFFRACTION / Resolution: 2.27 Å

PDB-1p6n:
Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide bound
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-1q2o:
Bovine endothelial nitric oxide synthase N368D mutant heme domain dimer with L-N(omega)-nitroarginine-2,4-L-diaminobutyramide bound
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-ACT:
ACETATE ION / Acetate

ChemComp-ZN:
Unknown entry

ChemComp-HEM:
PROTOPORPHYRIN IX CONTAINING FE / Heme B

ChemComp-H4B:
5,6,7,8-TETRAHYDROBIOPTERIN / neurotransmitter*YM / Tetrahydrobiopterin

ChemComp-DP1:
L-N(OMEGA)-NITROARGININE-2,4-L-DIAMINOBUTYRIC AMIDE

ChemComp-HOH:
WATER / Water

ChemComp-DP3:
N-{(4S)-4-AMINO-5-[(2-AMINOETHYL)AMINO]PENTYL}-N'-NITROGUANIDINE

ChemComp-DP9:
L-N(OMEGA)-NITROARGININE-(4R)-AMINO-L-PROLINE AMIDE

ChemComp-MTL:
D-MANNITOL / medication*YM / Mannitol

ChemComp-CAC:
CACODYLATE ION / Cacodylic acid

ChemComp-GOL:
GLYCEROL / Glycerol

Source
  • rattus norvegicus (Norway rat)
  • bos taurus (cattle)
KeywordsOXIDOREDUCTASE / nitric oxide synthase / heme-enzyme / endothelial nitric oxide synthase / enos / nos III / heme protein

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