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Structure paper

TitleStructural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
Journal, issue, pagesMol. Cell, Vol. 12, Page 1379-1389, Year 2003
Publish dateDec 3, 2003 (structure data deposition date)
AuthorsHu, J. / Liu, J. / Ghirlando, R. / Saltiel, A.R. / Hubbard, S.R.
External linksMol. Cell / PubMed:14690593
MethodsX-ray diffraction
Resolution2.3 - 2.6 Å
Structure data

PDB-1rpy:
CRYSTAL STRUCTURE OF THE DIMERIC SH2 DOMAIN OF APS
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-1rqq:
Crystal Structure of the Insulin Receptor Kinase in Complex with the SH2 Domain of APS
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-MN:
Unknown entry

ChemComp-112:
THIOPHOSPHORIC ACID O-((ADENOSYL-PHOSPHO)PHOSPHO)-S-ACETAMIDYL-DIESTER

Source
  • rattus norvegicus (Norway rat)
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / ADAPTER PROTEIN / SH2 DOMAIN / TRANSFERASE/SIGNALING PROTEIN / Protein tyrosine kinase / adaptor protein / TRANSFERASE-SIGNALING PROTEIN COMPLEX

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