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-Structure paper
Title | Hydrolysis of third-generation cephalosporins by class C beta-lactamases. Structures of a transition state analog of cefotoxamine in wild-type and extended spectrum enzymes. |
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Journal, issue, pages | J. Biol. Chem., Vol. 279, Page 9344-9352, Year 2004 |
Publish date | Nov 13, 2003 (structure data deposition date) |
Authors | Nukaga, M. / Kumar, S. / Nukaga, K. / Pratt, R.F. / Knox, J.R. |
External links | J. Biol. Chem. / PubMed:14660590 |
Methods | X-ray diffraction |
Resolution | 1.37 - 1.52 Å |
Structure data | PDB-1rgy: PDB-1rgz: |
Chemicals | ChemComp-PTX: ChemComp-MPD: ChemComp-HOH: ChemComp-GOL: |
Source |
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Keywords | HYDROLASE / cephalosporinase / enzyme inhibition / phosphonate / beta-lactam antibiotics / drug design |