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TitleEnzyme assisted suicide: Molecular basis for the antifungal activity of 5-hydroxy-4-oxonorvaline by potent inhibition of homoserine dehydrogenase
Journal, issue, pagesChem. Biol., Vol. 10, Page 989-995, Year 2003
Publish dateAug 18, 2003 (structure data deposition date)
AuthorsJacques, S.L. / Mirza, I.A. / Ejim, L. / Koteva, K. / Hughes, D.W. / Green, K. / Kinach, R. / Honek, J.F. / Lai, H.K. / Berghuis, A.M. / Wright, G.D.
External linksChem. Biol. / PubMed:14583265
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-1q7g:
Homoserine Dehydrogenase in complex with suicide inhibitor complex NAD-5-hydroxy-4-Oxonorvaline
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-NA:
Unknown entry

ChemComp-NHO:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE-5-HYDROXY-4-OXONORVALINE

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsOXIDOREDUCTASE

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