タイトル | Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines |
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ジャーナル・号・ページ | Bioorg. Med. Chem. Lett., Vol. 13, Page 2955-, Year 2003 |
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掲載日 | 2002年6月10日 (構造データの登録日) |
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著者 | Beattie, J.F. / Breault, G.A. / Ellston, R.P.A. / Green, S. / Jewsbury, P.J. / Midgley, C.J. / Naven, R.T. / Minshull, C.A. / Pauptit, R.A. / Tucker, J.A. / Pease, J.E. |
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リンク | Bioorg. Med. Chem. Lett. / PubMed:12941311 |
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手法 | X線回折 |
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解像度 | 1.6 - 2.31 Å |
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構造データ | PDB-1h00: CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-1h01: CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-1h07: CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-1h08: CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-1v1k: CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR 手法: X-RAY DIFFRACTION / 解像度: 2.31 Å |
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化合物 | ChemComp-FAP: (2S)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL
ChemComp-FCP: (2R)-1-[4-({6-[(2,6-DIFLUOROPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL
ChemComp-FAL: (2R)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL
ChemComp-FBL: (2S)-1-[4-({4-[(2,5-DICHLOROPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENOXY]-3-(DIMETHYLAMINO)PROPAN-2-OL
ChemComp-MFP: ((2-BROMO-4-METHYLPHENYL){6-[(4-{[(2R)-3-(DIMETHYLAMINO)-2-HYDROXYPROPYL]OXY}PHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)ACETONITRILE
ChemComp-MFQ: ((2-BROMO-4-METHYLPHENYL){6-[(4-{[(2S)-3-(DIMETHYLAMINO)-2-HYDROXYPROPYL]OXY}PHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)ACETONITRILE
ChemComp-BYP: (2R)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL
ChemComp-BWP: (2S)-1-{4-[(4-ANILINO-5-BROMOPYRIMIDIN-2-YL)AMINO]PHENOXY}-3-(DIMETHYLAMINO)PROPAN-2-OL
ChemComp-3FP: (2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL
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由来 | - homo sapiens (ヒト)
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キーワード | TRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / MITOSIS |
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